Deep Cholesterol Binding Sites on Mammalian Membrane Proteins
Porins Etc.
[Subunits identified as in the PDB file, followed by the TM helix number; Units of E, kcals/mol with molar concentration units].
| E | Donor | Acceptor | Local Residues (within 3 Å of a cholesterol –OH group) | |||
| Aquaporins | ||||||
| AQPO aquaporin lens, cow, 1ymg | ||||||
| None | ||||||
| AQPO aquaporin lens, sheep, 1sor | ||||||
| None | ||||||
| AQPO aquaporinn lens, sheep, 2b6o | ||||||
| None | ||||||
| AQPO aquaporin lens, sheep, 2b6p | ||||||
| None | ||||||
| AQPO aquaporin lens, sheep, 3m9i | ||||||
| None | ||||||
| AQP1 aquaporin red blood cell, human, 4csk | ||||||
| None | ||||||
| AQP1 aquaporin red blood cell, cow, 1j4n | ||||||
| None | ||||||
| AQP2 aquaporin, kidney, human, 4nef | ||||||
| None | ||||||
| AQP4 aquaporin glial cell, rat, 2d57 | ||||||
| -5.8 | Chl | OH | Thr120 [A3] | OG1 | Thr120 [A3] | |
| AQP4 aquaporin glial cell, mutant, rat, 2zz9 | ||||||
| -5.7 | Chl | OH | Thr120 [A3] | OG1 | Thr120 [A3] | |
| AQP4 aquaporin, human, 3gd8 | ||||||
| None | ||||||
| AQP5 aquaporin, human, 3d9s | ||||||
| None | ||||||
| SoPIP2 plant aquaporin, spinach, mutant, 3cll | ||||||
| None | ||||||
| SoPIP2 plant aquaporin, spinach, mutant, 3cn5 | ||||||
| None | ||||||
| SoPIP2 plant aquaporin, spinach, mutant, 3cn6 | ||||||
| None | ||||||
| TIP2, ammonia-permeable aquaporin, Arabidopsis, 5i32 | ||||||
| None | ||||||
| Urea Transporters | ||||||
| UT-B, cow, 4ezc | ||||||
| -7.6 | Chl | OH | Ala147 [A3] | O | Ala147 [A3] | Thr151 [A3] |
| Chl | OH | Thr151 [A3] | OG1 | |||
| Thr151 [A3] | OG1 | Chl | OH | |||
| UT-B bound to selenourea, cow, 4ezd | ||||||
| -7.0 | Chl | OH | Thr151 [A3] | OG1 | Ala147 [A3] | Thr151 [A3] |
| Rh ammonia channel | ||||||
| Rh C glycoprotein ammonia transporter, human, 3hd6 | ||||||
| None | ||||||